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Pathology of the Developing Mouse: A Systematic Approach

A systematic guide to identifying, characterising and interpreting developmental defects in mice.
Reading guide
This is a reference book, so it can be read in order or dipped into as needed. Readers new to the field will find it easiest to start with the baseline anatomy and developmental timelines before moving on to the protocols.
The book moves from normal anatomy and developmental timelines, through experimental design and statistics, to the examination methods and interpretation of abnormal findings in the animal and placenta.

Description

Spotting a malformed mouse embryo is only the start. Brad Bolon's reference, published by CRC Press in 2020, covers how to identify, characterise and interpret developmental defects from embryo and fetus through neonate and juvenile, with the placenta given its own attention. It opens with normal anatomy and physiology at each stage, alongside developmental timelines for the major organs and systems.

The book then moves on to experimental design and statistics, and to practical protocols for processing tissue and examining it at macroscopic, microscopic and ultrastructural levels. It also covers clinical pathology testing and in situ molecular analysis. Full-colour illustrations set normal development beside the main categories of defect, and the generous citations offer a route into further reading. It is written as a bench companion for pathologists and biomedical researchers working with mouse models.

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