Pathology of the Developing Mouse: A Systematic Approach

Spotting a malformed mouse embryo is one thing; working out what went wrong, and when, is another. Brad Bolon's reference sets out how to identify, characterise and interpret developmental defects in mice, from embryo and fetus through neonate and juvenile, with the placenta given its due. It begins with the baseline: normal anatomy and physiology at each stage, and developmental timelines for the major organs and systems.

From there it moves through sound experimental design and statistics, then practical protocols for processing tissue, examining it at macroscopic, microscopic and ultrastructural levels, clinical pathology testing and in situ molecular analysis. Full-colour illustrations show normal development alongside the main categories of defect, and generous citations point the way to further reading. A dependable bench companion for pathologists and biomedical researchers working with mouse models.